Evidence supporting the use of: Vitamin E (unspecified)
For the health condition: Macular Degeneration

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been studied for its potential role in supporting eye health and slowing the progression of age-related macular degeneration (AMD). The most significant scientific evidence comes from the Age-Related Eye Disease Study (AREDS), a large, randomized, controlled trial sponsored by the National Eye Institute. The AREDS formulation, which included vitamin E (400 IU daily) along with vitamin C, beta-carotene, zinc, and copper, was shown to reduce the risk of progression to advanced AMD by about 25% in people at high risk (with intermediate or advanced disease in one eye). However, vitamin E was not studied as a standalone intervention; its benefit was observed as part of the combination supplement. Subsequent studies, including AREDS2, replaced beta-carotene with lutein and zeaxanthin but retained vitamin E, and similar protective effects were found. There is no strong evidence that vitamin E alone prevents or treats AMD or benefits those without existing eye disease. Overall, while vitamin E is present in science-based formulations for AMD, the evidence supporting its independent effect is limited, and its use is primarily justified as part of a broader antioxidant strategy rather than as a solo therapy.

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