Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in various plants such as celery, parsley, and chamomile. Its use in supporting or treating lupus is primarily based on scientific investigations rather than traditional medicine. Preclinical studies have demonstrated that luteolin possesses notable anti-inflammatory, antioxidant, and immunomodulatory properties—mechanisms relevant to the pathogenesis of systemic lupus erythematosus (SLE). In animal models of lupus, luteolin has been shown to decrease the production of pro-inflammatory cytokines (such as TNF-α and IL-6), reduce the activation of immune cells like T cells and B cells, and mitigate oxidative stress, all of which are factors implicated in lupus flare-ups and tissue damage.

Despite these promising findings in laboratory and animal studies, there is currently a lack of robust clinical trials in humans directly assessing the efficacy and safety of luteolin for lupus patients. Most evidence comes from in vitro or animal research, and there are no established guidelines or recommendations for its use in lupus from major rheumatology organizations. Thus, while the scientific rationale and preclinical evidence suggest potential benefits, the overall quality of evidence remains low (rated 2 out of 5), pending further clinical validation. Patients should consult healthcare professionals before considering luteolin supplementation as part of lupus management.

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