Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Frangula (commonly known as buckthorn bark, specifically Frangula alnus or Rhamnus frangula) has a long history of traditional use as a herbal remedy to support the large intestines, particularly as a laxative to relieve occasional constipation. The primary active constituents in frangula bark are anthraquinone glycosides, which act as stimulant laxatives by increasing colonic motility and reducing water absorption in the colon, thus softening stools and promoting bowel movements. This use is well-documented in traditional European herbal medicine, and the bark has been included in several pharmacopeias for this purpose.

Although there is some understanding of the mechanism of action based on its phytochemistry, robust clinical trials on frangula bark’s efficacy and safety in modern populations are limited. Most of the supporting evidence comes from historical texts, traditional use, and extrapolation from related plants (like cascara sagrada, Rhamnus purshiana), which contain similar compounds. Regulatory authorities in some countries still allow the use of frangula bark for short-term relief of constipation, but they often warn against long-term use due to the risk of potential side effects such as electrolyte imbalance and dependency.

In summary, frangula is used to support the large intestine based on strong traditional use and plausible pharmacological action, but scientific validation through rigorous clinical trials is limited, justifying a mid-level evidence rating.

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