Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Biopeptides—often referred to as bioactive peptides—are short chains of amino acids derived from proteins, including sources such as collagen, that have demonstrated biological activity in the body. In the context of joint health, scientific interest has focused particularly on collagen-derived peptides, which are sometimes branded as "biopeptides." Several clinical studies have investigated the effects of collagen peptides on joint pain and function, particularly in individuals with osteoarthritis or exercise-induced joint discomfort.

Randomized controlled trials suggest that oral supplementation with collagen peptides may modestly improve joint pain and function. Proposed mechanisms include the stimulation of extracellular matrix production in cartilage and modulation of inflammatory processes. A 2012 systematic review in Current Medical Research and Opinion and subsequent studies have reported improvements in pain and mobility, especially in populations with mild joint degeneration. However, while some results are promising, the overall quality of evidence is moderate due to heterogeneity in study design, peptide formulation, and outcome measures.

Direct evidence for other types of biopeptides (not derived from collagen) in supporting joint health is limited. The bulk of positive data pertains to collagen-based preparations, which are bioactive by definition. Therefore, there is a scientific basis for the use of certain biopeptides—particularly collagen peptides—to support joint health, but further high-quality research is warranted to confirm efficacy and clarify mechanisms.

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