Self-Heal (Prunella vulgaris) has a long history of use in traditional herbal medicine, including in European, Chinese, and Native American systems. In traditional Chinese medicine (TCM), Self-Heal—known as Xiakucao—has been used to "clear liver fire" and is sometimes included in formulations for liver-related ailments, including jaundice. Historical herbal texts from Europe and Asia reference Self-Heal as a remedy for a variety of liver complaints, though often in the context of its broader "cooling" or anti-inflammatory properties rather than for jaundice specifically.

However, modern scientific studies directly evaluating the efficacy of Self-Heal for jaundice in adults are lacking. While the plant contains compounds with antioxidant and hepatoprotective potential, such as rosmarinic acid and flavonoids, there is currently no robust clinical evidence demonstrating its effectiveness in treating jaundice or underlying liver dysfunction in humans. Most of the support for its use in this context is thus rooted in traditional practices rather than validated by contemporary science.

In summary, Self-Heal's use for jaundice is primarily justified by traditional medicine systems, with minimal scientific validation; therefore, the evidence rating is low.