Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kaempferol is a natural flavonoid found in various plant foods such as kale, tea, and broccoli. Its use in supporting or treating Inflammatory Bowel Disorders (IBD), including Crohn’s disease and ulcerative colitis, is primarily justified by emerging scientific studies rather than by traditional medicine. Preclinical research using in vitro and animal models has demonstrated that kaempferol possesses anti-inflammatory and antioxidant properties. Specifically, studies have shown that kaempferol can inhibit pro-inflammatory cytokines (like TNF-α, IL-6, and IL-1β), reduce oxidative stress, and modulate signaling pathways such as NF-κB and MAPK, which are implicated in the pathogenesis of IBD. For example, rodent models of colitis have shown reduced inflammation and tissue damage with kaempferol supplementation. However, there is a lack of robust clinical trials in humans to confirm these benefits in IBD patients. Current evidence is thus limited to laboratory and animal studies, and while the mechanistic rationale for kaempferol’s use is strong, its efficacy and safety in humans with IBD have not been established. Therefore, while the use of kaempferol for IBD is scientifically plausible and supported by preclinical data, clinical evidence is insufficient, and its use should be considered experimental rather than established.

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