Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 polyunsaturated fatty acid found primarily in fish oil. Its use in inflammatory bowel disorders (IBD), such as Crohn’s disease and ulcerative colitis, is based on its known anti-inflammatory properties. Several preclinical studies have demonstrated that DHA can reduce markers of inflammation and support mucosal healing in animal models of colitis. Mechanistically, DHA is believed to modulate inflammatory pathways through the production of specialized pro-resolving mediators, inhibition of pro-inflammatory cytokines (such as TNF-α and IL-1β), and alteration of cell membrane phospholipid composition, which can affect immune cell function. However, clinical data in humans are mixed and generally modest. Some small trials and observational studies suggest that higher dietary intake of DHA and EPA (another omega-3) may be associated with reduced risk or severity of IBD, but larger randomized controlled trials have not consistently shown significant improvements in remission rates, relapse prevention, or symptom control when compared to placebo. Moreover, most studies use a combination of DHA and EPA, making it difficult to isolate the specific effects of DHA. Overall, while there is a scientific rationale and some supportive evidence for the use of DHA in IBD, the clinical benefits appear limited and inconsistent. Thus, the strength of evidence is rated as 2 out of 5, indicating some scientific basis but insufficient robust clinical validation for routine therapeutic use.

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Nature's Sunshine Circulatory System
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Trio