Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a sesquiterpene compound found in the rhizome of Atractylodes macrocephala, a traditional Chinese medicinal herb. The use of Atractylodes macrocephala (commonly known as Bai Zhu) for the treatment of indigestion and related gastrointestinal disorders has a long history in East Asian traditional medicine. Its application is primarily based on traditional Chinese medicine (TCM) principles, where it is believed to strengthen the "Spleen" and improve digestive function, addressing symptoms like bloating, poor appetite, and diarrhea.

While preclinical studies have identified atractylone as one of the main bioactive constituents and demonstrated some pharmacological activities—such as anti-inflammatory, gastroprotective, and immunomodulatory effects—there is a lack of robust clinical trials specifically evaluating atractylone alone for indigestion in humans. Most available evidence comes from animal studies or research using crude extracts of the whole herb rather than the isolated compound. Thus, while there is some preliminary scientific rationale for its potential effects on gastrointestinal function, the primary justification for its use in indigestion remains traditional. The evidence rating is 2, as limited animal and in vitro data exist, but human clinical validation is lacking.

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