Evidence supporting the use of: Ibutamoren
For the body system: Hypothalamus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ibutamoren (also known as MK-677) is a non-peptide agonist of the ghrelin receptor and a potent stimulator of growth hormone (GH) secretion. Its effects are primarily on the endocrine system, specifically the hypothalamic-pituitary axis. Scientific studies in both animals and humans demonstrate that ibutamoren increases circulating levels of GH and insulin-like growth factor 1 (IGF-1) by mimicking the action of ghrelin, a hormone produced in the hypothalamus. This leads to stimulation of the pituitary gland to release growth hormone. Clinical trials have shown that ibutamoren can increase GH and IGF-1 levels in healthy adults, elderly subjects, and those with GH deficiencies.

However, most research is focused on its potential for increasing muscle mass, bone density, and aiding recovery—not direct “support” of hypothalamic health or function per se. The hypothalamus is involved indirectly because it is the origin of the hormonal signaling cascade affected by ibutamoren. No studies specifically demonstrate that ibutamoren improves hypothalamic function beyond its role in hormone regulation. Thus, while there is some scientific evidence for its effect on the hypothalamic-pituitary axis, the evidence directly supporting its use for “hypothalamus body system support” is moderate and not yet robustly established.

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Products containing Ibutamoren

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