Evidence supporting the use of: Xanthohumol
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Xanthohumol is a prenylated flavonoid found primarily in hops (Humulus lupulus), which are used in beer brewing. There is a growing body of scientific evidence suggesting that Xanthohumol has hepatoprotective (liver-protective) properties. Preclinical studies, including in vitro and animal models, have demonstrated that Xanthohumol exerts antioxidant, anti-inflammatory, and anti-fibrotic effects in the liver. For example, research published in journals such as Archives of Biochemistry and Biophysics and Food and Chemical Toxicology has shown that Xanthohumol can reduce oxidative stress, suppress inflammatory cytokines, and prevent the progression of liver fibrosis in rodent models of liver injury.
Xanthohumol has also been investigated for its role in modulating enzymes involved in detoxification and in reducing fat accumulation in the liver, which are relevant for conditions such as non-alcoholic fatty liver disease (NAFLD). However, most studies to date have been conducted in animals or cell cultures, and there are only limited clinical trials in humans. Thus, while the mechanistic and preclinical data are promising and provide a rationale for supporting hepatic health, high-quality human studies are still needed to confirm efficacy and safety in the context of liver support.
In summary, the use of Xanthohumol to support the hepatic system is primarily justified by scientific evidence from preclinical research, but further clinical validation is necessary.
Other ingredients that support Hepatic System
amino acidsartichoke
barberry
berberine
black garlic
bovine
bovine liver
broccoli
bupleurum falcatum
turmeric
curcumin
d-glucarate
dandelion
epigallocatechin gallate (EGCG)
fructose
garlic bulb
gentian root
gooseberry
green tea
hesperetin
kale
l-glutathione
l-methionine
l-ornithine
lecithin
liquid liver fractions
matcha
milk thistle
n-acetyl-cysteine (NAC)
naringin
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
olive
ox bile
pantethine
parsley
phenolic acids
phosphatidylcholine
phospholipids
pumpkin
riboflavin (vitamin B2)
silymarin
sulforaphane glucosinolate
tocotrienols
trimethylglycine (TMG)
triphala
vitamin B
water
watercress
zinc
jiaogulan
punarnava
picrorhiza kurroa
lingzhi
bile salt
ferulic acid
ganoderma
polyphenols
trace minerals
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
Apigenin
Antrodia camphorata
Arginine carglumate
AHCC
Andrographolide
Alpha-Lipoic Acid
Ampelopsin
Animal protein
Black Seed
Borotutu
Brassica
Beef liver
Baicalein
Basidiomycota
boldo
Betanin
berry
Bitter principals
bile acid
Bupleurum
Boerhavia diffusa
cholic acid
Carqueja
Catalpol
Coenzyme A
Capillary Artemisia
chlorogenic acid
Curcuminoid
Cynarin
Cruciferous
Capers
Chanca Piedra
Curcuma
Chinese Thoroughwax
Corilagin
Cynaropicrin
Dihydromyricetin
DL-Methionine
Dehydrocholic acid
Dihydrolipoic Acid
Dithiolthiones
Eriocitrin
Egg
Eclipta
Emblicanin
Fringetree
Flavonolignan
Ginsenosides
Gamma-Glutamylcysteine
Gallate
glucose
Glycocholic acid
Glycyrrhetinic Acid
Glycyrrhizin
Gentiana manshurica
Glycochenodeoxycholic acid
Other body systems supported by Xanthohumol
ArteriesBrain
Circulatory System
Gastrointestinal Tract
Heart
Hepatic System
Immune System
Intestinal System
Liver