Evidence supporting the use of: Polydatin
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Polydatin, also known as piceid, is a natural precursor of resveratrol found in Polygonum cuspidatum (Japanese knotweed) and other plants. Its use for supporting the hepatic (liver) system is scientifically investigated, primarily in preclinical studies. Research has demonstrated that polydatin exhibits hepatoprotective effects in various animal models of liver injury, such as those induced by carbon tetrachloride, alcohol, and high-fat diets. The proposed mechanisms include antioxidant activity, reduction of inflammatory cytokines, inhibition of hepatic fibrosis, and modulation of signaling pathways like NF-κB and Nrf2. For example, studies published in peer-reviewed journals report that polydatin administration can attenuate oxidative stress, decrease levels of liver enzymes (ALT, AST), and reduce histopathological changes in liver tissue.
However, while these findings provide promising evidence, most data come from animal or in vitro studies. There are currently limited clinical trials in humans assessing polydatin’s efficacy for liver health. Thus, its use for hepatic support is based on preclinical scientific validation rather than established clinical efficacy or longstanding traditional use specific to the liver. More research, particularly in human populations, is needed to confirm its benefit and safety for hepatic support.
Other ingredients that support Hepatic System
amino acidsartichoke
barberry
berberine
black garlic
bovine
bovine liver
broccoli
bupleurum falcatum
turmeric
curcumin
d-glucarate
dandelion
epigallocatechin gallate (EGCG)
fructose
garlic bulb
gentian root
gooseberry
green tea
hesperetin
kale
L-glutathione
L-methionine
L-Ornithine
lecithin
liquid liver fractions
matcha
milk thistle
n-acetyl-cysteine (NAC)
naringin
niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
olive
ox bile
pantethine
parsley
phenolic compounds
phosphatidylcholine
phospholipids
pumpkin
riboflavin (vitamin B2)
schisandra chinensis
silymarin
sulforaphane glucosinolate
tocotrienols
trimethylglycine (TMG)
triphala
vitamin B
water
watercress
zinc
jiaogulan
punarnava
picrorhiza kurroa
lingzhi
bile salt
ferulic acid
ganoderma
polyphenols
trace minerals
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
Apigenin
Antrodia camphorata
Arginine carglumate
AHCC
Andrographolide
Alpha-Lipoic Acid
Ampelopsin
Animal protein
Black Seed
Borotutu
Brassica
Beef liver
Baicalein
Basidiomycota
boldo
Betanin
berry
Bitter principals
bile acid
Bupleurum
Boerhavia diffusa
cholic acid
Carqueja
Catalpol
Coenzyme A
Capillary Artemisia
chlorogenic acid
Curcuminoid
Cynarin
Cruciferous
Capers
Chanca Piedra
Curcuma
Chinese Thoroughwax
Corilagin
Cynaropicrin
Dihydromyricetin
DL-Methionine
Dehydrocholic acid
Dihydrolipoic Acid
Dithiolthiones
Eriocitrin
Egg
Eclipta
Emblicanin
Fungus
Fringetree
Flavonolignan
Ginsenosides
Gypenoside
Gamma-Glutamylcysteine
Gallate
glucose
Glycocholic acid
Glycyrrhetinic Acid
Guggulsterones
Glycyrrhizin
Gentiana manshurica
Glycochenodeoxycholic acid
Isosilybin
isoliquiritigenin
Jurubeba
Kutkins
Maslinic Acid
Mangiferin
Monoterpenes
Myricetin
Mushroom
Naringenin
Nigella Seed
Nobiletin
Oxymatrine
Ornithine l-aspartic acid
Phyllanthus
Puerarin
Phenylpropanoids
Picroside
Pentacyclic triterpenoids
Polydatin
Phthalides
Pu-Er Tea
Polymethoxylated flavones
Plukenetia volubilis
Scoparia dulcis
Silybin
Salvianolic acid
Schisandrins
Silydianin
Silychristin
Schizandrol A
Silybum
S-allylcysteine
Sesamin
Sulforaphane
Terminalia
Terpenoids
Thymoquinone
Taxifolin
Thistle
Taurochenodeoxycholic acid
Taurocholic acid
Triterpenes
Taurodeoxycholic acid
Taraxacum
Theabrownin
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
Other body systems supported by Polydatin
ArteriesBlood
Brain
Capillaries
Circulatory System
Heart
Hepatic System
Immune System
Intestinal System
Kidneys
Liver
Mitochondria
Respiratory System
Skin
Veins
