Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacin (vitamin B3) has been studied for its effects on the hepatic (liver) system, primarily due to its role in lipid metabolism. Scientifically, niacin is known to lower cholesterol and triglyceride levels, which can have indirect benefits for liver health, especially in conditions such as nonalcoholic fatty liver disease (NAFLD). Some clinical studies have shown that niacin can reduce hepatic steatosis (fat accumulation in the liver) by improving lipid profiles. However, its use in liver support is limited by the potential for hepatotoxicity at high doses, with side effects including elevated liver enzymes and, in rare cases, liver failure. While niacin is essential for general cellular metabolism and is required for the synthesis of NAD/NADP, which are crucial for hepatic energy metabolism, its direct therapeutic use for liver diseases is not widely endorsed in clinical guidelines, except in specific circumstances related to lipid disorders. Overall, while there is some scientific rationale and evidence for niacin influencing liver health, especially via lipid modulation, its use for general hepatic support is not robustly established and is limited by safety concerns. Therefore, it receives a moderate evidence rating.

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amino acids
artichoke
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bovine liver
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bupleurum falcatum
turmeric
curcumin
d-glucarate
dandelion
epigallocatechin gallate (EGCG)
fructose
garlic bulb
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ox bile
pantethine
parsley
phenolic compounds
phosphatidylcholine
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riboflavin (vitamin B2)
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