Evidence supporting the use of: Lipoic Acid
For the body system: Hepatic System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lipoic acid (also known as alpha-lipoic acid or ALA) is a compound that has been studied for its potential benefits in supporting the hepatic (liver) system. Scientific evidence suggests that lipoic acid acts as a potent antioxidant, helping to neutralize free radicals and reduce oxidative stress in liver tissues. Several animal studies and limited human trials have explored the use of lipoic acid in conditions such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and drug-induced liver injury. Results often show improvements in biomarkers of liver health, including reduced inflammation and improved liver enzyme profiles.

Lipoic acid is also known to regenerate other antioxidants, such as glutathione, which is crucial for liver detoxification processes. Some clinical evidence suggests that supplementation may help improve insulin sensitivity and reduce liver fat accumulation in people with metabolic syndrome, a key risk factor for liver disease. However, while the mechanistic rationale and early studies are promising, large-scale, high-quality randomized controlled trials in humans are still limited. Therefore, its use is best considered as complementary, rather than primary, therapy for liver support at this time.

In summary, lipoic acid is supported by a moderate level of scientific evidence for hepatic health, primarily due to its antioxidant activity, but further research is needed to establish robust clinical guidelines.

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Products containing Lipoic Acid

We currently have no products on Caring Sunshine that contain this ingredient.