Evidence supporting the use of: EGCG
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Epigallocatechin gallate (EGCG) is a major catechin found in green tea (Camellia sinensis). Its use to support the hepatic (liver) system has scientific backing, although most evidence comes from preclinical studies and a limited number of human trials. EGCG possesses antioxidant, anti-inflammatory, and anti-fibrotic properties, which are thought to be beneficial in protecting liver cells from damage. Animal and in vitro studies have demonstrated that EGCG can reduce oxidative stress and inhibit the progression of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and liver fibrosis by modulating cellular signaling pathways and reducing lipid accumulation in hepatocytes.
Some small-scale clinical studies have explored the effects of green tea extracts (rich in EGCG) in humans with liver disorders. These trials reported improvements in liver enzyme levels and reductions in markers of inflammation and fat accumulation. However, the overall quality of human evidence remains moderate; larger and more rigorous randomized controlled trials are needed for definitive conclusions.
It is important to note that while EGCG has potential hepatoprotective effects, high doses have been associated with rare cases of hepatotoxicity. Thus, dosage and individual susceptibility are important considerations. In summary, EGCG is scientifically investigated for liver support and shows promise, but evidence is not yet robust enough to warrant strong recommendations for clinical use.
Other ingredients that support Hepatic System
amino acidsartichoke
barberry
berberine
black garlic
bovine
bovine liver
broccoli
bupleurum falcatum
turmeric
curcumin
d-glucarate
dandelion
epigallocatechin gallate (EGCG)
fructose
garlic bulb
gentian root
gooseberry
green tea
hesperetin
kale
L-glutathione
L-methionine
L-Ornithine
lecithin
liquid liver fractions
matcha
milk thistle
n-acetyl-cysteine (NAC)
naringin
niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
olive
ox bile
pantethine
parsley
phenolic compounds
phosphatidylcholine
phospholipids
pumpkin
riboflavin (vitamin B2)
schisandra chinensis
silymarin
sulforaphane glucosinolate
tocotrienols
trimethylglycine (TMG)
triphala
vitamin B
water
watercress
zinc
jiaogulan
punarnava
picrorhiza kurroa
lingzhi
bile salt
ferulic acid
ganoderma
polyphenols
trace minerals
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
Apigenin
Antrodia camphorata
Arginine carglumate
AHCC
Andrographolide
Alpha-Lipoic Acid
Ampelopsin
Animal protein
Black Seed
Borotutu
Brassica
Beef liver
Baicalein
Basidiomycota
boldo
Betanin
berry
Bitter principals
bile acid
Bupleurum
Boerhavia diffusa
cholic acid
Carqueja
Catalpol
Coenzyme A
Capillary Artemisia
chlorogenic acid
Curcuminoid
Cynarin
Cruciferous
Capers
Chanca Piedra
Curcuma
Chinese Thoroughwax
Corilagin
Cynaropicrin
Dihydromyricetin
DL-Methionine
Dehydrocholic acid
Dihydrolipoic Acid
Dithiolthiones
Eriocitrin
Egg
Eclipta
Emblicanin
Fungus
Fringetree
Flavonolignan
Ginsenosides
Gypenoside
Gamma-Glutamylcysteine
Gallate
glucose
Glycocholic acid
Glycyrrhetinic Acid
Guggulsterones
Glycyrrhizin
Gentiana manshurica
Glycochenodeoxycholic acid
Isosilybin
isoliquiritigenin
Jurubeba
Kutkins
Maslinic Acid
Mangiferin
Monoterpenes
Myricetin
Mushroom
Naringenin
Nigella Seed
Nobiletin
Oxymatrine
Ornithine l-aspartic acid
Phyllanthus
Puerarin
Phenylpropanoids
Picroside
Pentacyclic triterpenoids
Polydatin
Phthalides
Pu-Er Tea
Polymethoxylated flavones
Plukenetia volubilis
Scoparia dulcis
Silybin
Salvianolic acid
Schisandrins
Silydianin
Silychristin
Schizandrol A
Silybum
S-allylcysteine
Sesamin
Sulforaphane
Terminalia
Terpenoids
Thymoquinone
Taxifolin
Thistle
Taurochenodeoxycholic acid
Taurocholic acid
Triterpenes
Taurodeoxycholic acid
Taraxacum
Theabrownin
Wogonin
Xanthohumol
Xanthorrhizol
Yin Chen
