Curcuminoids, the active polyphenolic compounds found in turmeric (Curcuma longa), are widely used to support hepatic (liver) health. Their use is supported by both traditional medicinal practices, especially in Ayurveda, and a substantial body of modern scientific research.

Scientific evidence indicates that curcuminoids possess hepatoprotective properties. Multiple animal studies have shown that curcumin can attenuate liver injury induced by toxins, alcohol, or high-fat diets, primarily through its antioxidant, anti-inflammatory, and antifibrotic effects. A 2016 systematic review (Panahi et al., 2016) reported beneficial effects of curcumin supplementation in patients with non-alcoholic fatty liver disease (NAFLD), including improved liver enzyme profiles and reduced markers of liver inflammation.

The mechanisms underlying these effects include inhibition of nuclear factor-kappa B (NF-κB), suppression of proinflammatory cytokines, and enhancement of antioxidant defenses via upregulation of glutathione. Some clinical trials have demonstrated that curcumin supplementation can reduce serum ALT and AST levels in individuals with liver disorders. However, bioavailability remains a challenge, and formulations designed to enhance absorption are often used in research and clinical settings.

While more large-scale, long-term human trials are needed to fully establish efficacy, the current body of evidence supports the use of curcuminoids as an adjunct for maintaining liver health and managing certain liver conditions.