Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Amino acids play a critical role in supporting the hepatic (liver) system, and their use is justified by scientific evidence. The liver is central to amino acid metabolism; it is responsible for the synthesis, catabolism, and conversion of amino acids into other biomolecules. In clinical settings, amino acids are included in medical nutrition therapy for patients with liver diseases such as cirrhosis, hepatic encephalopathy, and liver failure. Specific amino acids, such as branched-chain amino acids (BCAAs: leucine, isoleucine, and valine), have been shown in randomized controlled trials and meta-analyses to improve outcomes in patients with hepatic encephalopathy by supporting nitrogen metabolism and reducing neurotoxic ammonia levels.

Furthermore, the liver requires a continuous supply of certain amino acids, such as methionine and cysteine, for the synthesis of glutathione, a key antioxidant that protects hepatocytes from oxidative stress. Protein-energy malnutrition is common in advanced liver disease, and supplementation with amino acids can help maintain muscle mass and overall protein balance. Guidelines from hepatology and nutrition societies recommend the use of amino acid supplementation, particularly BCAAs, in specific liver conditions. However, the evidence is stronger for hepatic encephalopathy and less robust for other liver diseases. Overall, the role of amino acids in liver health is well-supported by mechanistic, clinical, and nutritional research.

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