Evidence supporting the use of: Acetyl-l-glutathione
For the body system: Hepatic System
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Acetyl-L-glutathione is a stabilized form of glutathione, a tripeptide composed of glutamine, cysteine, and glycine, which is a key antioxidant in cellular defense systems. Glutathione plays a critical role in hepatic (liver) detoxification processes, particularly in neutralizing reactive oxygen species and facilitating the conjugation and elimination of various toxins. The rationale for using acetyl-L-glutathione as a supplement is that oral glutathione is rapidly broken down in the digestive tract, whereas the acetylated form is thought to be more bioavailable and capable of increasing systemic glutathione levels, including in the liver. Several animal studies and limited human studies suggest that increasing glutathione levels can support liver health, especially in conditions of oxidative stress or toxin exposure. However, direct evidence from controlled clinical trials specifically investigating acetyl-L-glutathione’s effects on liver function is limited. Most available research focuses on glutathione in general, not the acetylated form. While acetyl-L-glutathione may theoretically benefit hepatic detoxification, the evidence base is modest and mainly extrapolated from studies on glutathione itself. In summary, while there is scientific rationale and some preliminary evidence supporting acetyl-L-glutathione for hepatic system support via its role as an antioxidant and detoxification molecule, high-quality human data specific to this compound are lacking. The evidence, therefore, can be considered modest but plausible.
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amino acidsartichoke
barberry
berberine
black garlic
bovine
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bupleurum falcatum
turmeric
curcumin
d-glucarate
dandelion
epigallocatechin gallate (EGCG)
fructose
garlic bulb
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gooseberry
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L-methionine
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liquid liver fractions
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naringin
niacin (vitamin B3)
niacinamide (Vitamin B3)
nicotinamide riboside
oleanolic acid
olive
ox bile
pantethine
parsley
phenolic compounds
phosphatidylcholine
phospholipids
pumpkin
riboflavin (vitamin B2)
schisandra chinensis
silymarin
sulforaphane glucosinolate
tocotrienols
trimethylglycine (TMG)
triphala
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ferulic acid
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polyphenols
trace minerals
herbal blend (proprietary)
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isoliquiritigenin
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Yin Chen
