Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, which includes both tocopherols and tocotrienols, has been investigated for its role in cardiovascular health due to its antioxidant properties. The rationale is that oxidative stress contributes to atherosclerosis and other forms of heart disease, and Vitamin E may help by reducing the oxidation of LDL cholesterol, a key event in the development of atherosclerosis. Some observational studies have suggested that higher dietary intake of Vitamin E is associated with lower rates of coronary heart disease. However, large randomized controlled trials (RCTs) have largely failed to show significant benefit from Vitamin E supplementation in reducing cardiovascular events or mortality in the general population or in those with established heart disease. Examples include the HOPE and GISSI-Prevenzione trials, which found no significant reduction in major cardiovascular outcomes with Vitamin E supplementation.

Tocotrienols, less studied than tocopherols, may have additional lipid-lowering and anti-inflammatory effects, but clinical evidence remains limited. Some small studies and preclinical research suggest possible benefits, but these have not yet translated into clear recommendations for clinical practice.

Overall, while Vitamin E is biologically plausible as a cardioprotective agent, the clinical evidence does not robustly support its use for treating or preventing "heart weakness" (heart failure or related conditions). Current guidelines do not recommend routine Vitamin E supplementation for cardiovascular disease prevention or treatment.

More about Vitamin E (mixied tocopherols and tocotrienols)
More about Heart (weakness)

Other ingredients used for Heart (weakness)

Other health conditions supported by Vitamin E (mixied tocopherols and tocotrienols)

Products containing Vitamin E (mixied tocopherols and tocotrienols)