Evidence supporting the use of: Smilagenin
For the body system: Glandular System
Synopsis
Source of validity: Traditional
Rating (out of 5): 1
Smilagenin is a steroidal sapogenin found primarily in plants of the Smilax genus, such as sarsaparilla. Its traditional use stems from indigenous and folk medicine practices, where sarsaparilla root preparations were believed to support the glandular system, particularly the adrenal and reproductive glands. These beliefs were largely based on the doctrine of signatures and the observation that plants containing steroid-like compounds could have effects similar to hormones in the human body. However, there is no robust scientific evidence directly linking smilagenin to glandular system support. Most of the claims are extrapolated from the structural similarity of smilagenin to endogenous steroid hormones, but clinical studies are lacking. The compound has not been widely studied in humans, and the supposed benefits for the glandular system remain unproven in rigorous scientific trials. Therefore, while its use is justified by tradition and historical herbal practices, the evidence supporting these claims is weak, and it is primarily anecdotal or based on preclinical data rather than well-controlled scientific research.
Other ingredients that support Glandular System
7-Keto-DHEAadrenal cortex
alfalfa
amino acids
ashwagandha
astragalus
waterhyssop
basil
black cohosh
sesame
bovine
bovine kidney
bovine liver
bovine pancreas
broccoli
brussel sprouts
bupleurum falcatum
bасора
caterpillar mushroom
chaga mushroom
chaste tree
cinnamon
coenzyme Q10 (CoQ10)
colostrum
Coptis chinensis
cordyceps
cowage seed
turmeric
turmeric
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
fennel
forskohlii root
fruit and vegetable blend (proprietary)
gamma linolenic acid (GLA)
garlic bulb
ginseng
gokhru
gooseberry
greek mountain tea
onion
green tea
greens blend (proprietary)
guayusa
guggul
iodine
iron
jujube
kale
kelp
l-tryptophan
l-tyrosine
lavender
licorice root
linoleic acid (LA)
liquid liver fractions
lophatherum leaf
maca
magnesium
maitake mushroom
manganese
melatonin
milk thistle
moringa
motherwort
nettle
niacin (vitamin B3)
oleanolic acid
omega-6 fatty acids
pantothenic acid (vitamin B5)
parsley
phytocannabinoids
pregnenolone
protein
pumpkin
pyridoxal-5-phosphate (P-5-P)
rehmannia glutinosa
reishi mushroom
rhodiola
riboflavin (vitamin B2)
rose oil
sage
saw palmetto
scrophularia root
selenium
soybean
tongkat ali
tribulus
vegetable blend (proprietary)
velvet bean
vitamin A
vitamin B
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
water
watercress
wheat grass
whole adrenal glandular
wild yam
zinc
β-nicotinamide mononucleotide (NMN)
red clover
suma
jiaogulan
gastrodia
capsicum
hedychium spicatum
tinospora cordifolia
bee pollen
lingzhi
dioscorea
eucommia
ganoderma
lotus seed
oriental arborvitae
royal jelly
polyphenols
trace minerals
anemarrhena asphodeloides
noni
hypothalamus
herbal blend (proprietary)
algae
thyroid substance
ashitaba
bladderwrack
7,8-Dihydroxyflavone
Aralia
Antler
Anamarrhena
Ajuga
Ascophyllum nodosum
Asteracea
Acemannan
Agnuside
Ashoka
Anemarrhena
Animal protein
Blue Cohosh
Black Seed
Babchi
Bidens pilosa
Brown Algae
Brassica
Beef
Beef liver
Barleria
Berberis (unspecified)
Bovine Protein
Bulbine natalensis
Brazil nut
Banyan
Barbasco
Bee products
Babassu
Bupleurum
Camellia sinensis
Cinnamomum
Clary sage
Chinese Mountain Ant
Cucurbita
Cod Liver Oil
Codonopsis
Cruciferous
Cyanotis Vaga
Chinese Thoroughwax
Ceanothus integerrimus
Celastrus
Canscora
Didymocarpus
DHEA
Dendrobium
diiodotyrosine
Deer Velvet
Dong Quai
Diosgenin
Devil's Club
Dwarf Morning Glory
Eurycomanone
Elk antler
Eurycoma Longifolia
Essential Oil Blend
Eucommia ulmoides
Fenuside
Figwort
Fo-Ti
Furostanols
Flat-stem milk-vetch
Fatty acids
False Unicorn Root
Fadogia agrestis
Forskolin
Ginsenosides
Golden eardrops
Guggulsterones
Glycyrrhizin
Gugglesterone
Himalayan Salt
jasmine
Molasses
Sandalwood
Tribulus Terrestris
Vervain
