Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Rehmannia glutinosa, a staple herb in Traditional Chinese Medicine (TCM), is primarily used based on traditional evidence to support the glandular (endocrine) system, particularly the adrenal glands. In TCM, Rehmannia is believed to "nourish Yin," "tonify the kidneys," and restore balance to bodily systems associated with hormonal and metabolic regulation. Its use is especially common in formulas intended to address symptoms of adrenal fatigue, menopause, and other endocrine imbalances. However, scientific research on Rehmannia’s effects on the glandular system in humans is limited. Most available studies are animal-based or in vitro, and focus on its anti-inflammatory, immunomodulatory, and antioxidant properties. A few animal studies suggest Rehmannia extracts may influence adrenal function and steroid hormone levels, but these findings have not been adequately validated in human trials. Some preliminary evidence also points to effects on blood glucose metabolism and potential support for thyroid function, but again, robust clinical validation is lacking. In summary, while Rehmannia glutinosa is widely used for glandular support in traditional herbal systems, there is insufficient scientific evidence from human studies to strongly support its efficacy or mechanism of action for this purpose. Its current use for the glandular system is best described as traditional, with a modest evidence rating.

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