Lingzhi, also known as Ganoderma lucidum or reishi mushroom, has been used for thousands of years in traditional Chinese medicine, often referred to as the "mushroom of immortality." In traditional practice, lingzhi is believed to support the Glandular System, particularly by nourishing and balancing the adrenal glands, enhancing vitality, and modulating the body's stress response. These effects are attributed to its adaptogenic properties, which are thought to help the body adapt to physical and emotional stress.

Scientifically, lingzhi contains bioactive compounds such as triterpenoids, polysaccharides, and peptidoglycans. Some studies suggest these compounds may influence hormone regulation and immune responses, but direct, robust evidence specifically linking lingzhi to broad support of the entire Glandular System is limited. Most research focuses on immune modulation and potential anti-stress effects, rather than explicit endocrine or glandular benefits. Therefore, while traditional use as a tonic for glandular health is well-established, modern scientific validation for this specific application remains preliminary and indirect.