Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has gained attention for its ability to act as a small-molecule agonist of the TrkB receptor, which is the primary receptor for brain-derived neurotrophic factor (BDNF). Most research has focused on its neuroprotective and cognitive-enhancing properties due to its effects on neuronal survival, plasticity, and synaptic function. There is emerging, but limited, scientific interest in how 7,8-DHF may influence the glandular system, particularly the hypothalamic-pituitary-adrenal (HPA) axis, which integrates neurological and endocrine functions. Animal studies have reported that 7,8-DHF can modulate stress responses and may have indirect effects on adrenal gland function by influencing BDNF-TrkB signaling pathways. However, direct clinical evidence for supporting the overall glandular system in humans is lacking. There are no established traditional uses of 7,8-DHF for glandular health, and its application in this area is primarily based on mechanistic plausibility and preclinical (mostly animal) models. Therefore, while there is some scientific rationale for its potential effects on certain glandular functions, especially those tightly linked to neuroendocrine regulation, robust validation in humans is currently insufficient.

More about 7,8-Dihydroxyflavone
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7-Keto-DHEA
adrenal cortex
alfalfa
amino acids
ashwagandha
astragalus
waterhyssop
basil
black cohosh
sesame
bovine
bovine kidney
bovine liver
bovine pancreas
broccoli
brussel sprouts
bupleurum falcatum
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chaste tree
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coenzyme Q10 (CoQ10)
colostrum
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cordyceps
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dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
fennel
forskohlii root
fruit and vegetable blend (proprietary)
gamma linolenic acid (GLA)
garlic bulb
ginseng
gokhru
gooseberry
greek mountain tea
onion
green tea
greens blend (proprietary)
guayusa
guggul
iodine
iron
jujube
kale
kelp
l-tryptophan
l-tyrosine
lavender
licorice root
linoleic acid (LA)
liquid liver fractions
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melatonin
milk thistle
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motherwort
nettle
niacin (vitamin B3)
oleanolic acid
omega-6 fatty acids
pantothenic acid (vitamin B5)
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phytocannabinoids
pregnenolone
protein
pumpkin
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riboflavin (vitamin B2)
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saw palmetto
scrophularia root
selenium
soybean
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vitamin A
vitamin B
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7,8-Dihydroxyflavone
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diiodotyrosine
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Other body systems supported by 7,8-Dihydroxyflavone

Brain
Glandular System
Hypothalamus
Nerves
Parasympathetic Nervous System
Sympathetic Nervous System

Products containing 7,8-Dihydroxyflavone

We currently have no products on Caring Sunshine that contain this ingredient.