Hedyotis, particularly Hedyotis diffusa (also known as Oldenlandia diffusa or Bai Hua She She Cao in Traditional Chinese Medicine), has been traditionally used in various Asian medicinal systems for a range of ailments, including liver and biliary disorders. Historical records and traditional herbal texts sometimes mention its use for promoting bile flow, reducing jaundice, and supporting liver health, which may be indirectly related to gallstone management. However, direct references to its use specifically for gallstones are limited and not prominent in traditional materia medica.

Scientific studies on Hedyotis diffusa have focused mostly on its anti-inflammatory, anti-tumor, and hepatoprotective effects. There is no robust clinical or preclinical evidence supporting its efficacy in dissolving gallstones or preventing their formation. The existing traditional use may be based on its broader indications for "clearing heat and toxins" and supporting liver and bile function, but these claims have not been rigorously validated by modern research in the context of cholelithiasis (gallstones).

In summary, the use of Hedyotis for gallstones is primarily based on traditional practice rather than scientific validation, and the evidence supporting its use for this specific condition is weak.