Herbal blends marketed for "gall bladder support" are most commonly justified by traditional use rather than robust scientific validation. Many such blends include herbs like artichoke leaf, turmeric, dandelion root, milk thistle, and others historically used in folk and traditional medicine for their purported effects on liver and gallbladder function. For example, artichoke and dandelion have been used in Europe as "choleretics" (to increase bile flow), while milk thistle is traditionally believed to support liver health, potentially aiding the gall bladder by association. However, most clinical trials are small, of low quality, or focus on liver rather than gall bladder health. Some animal studies suggest increased bile flow with certain herbs, but human evidence is sparse and not specific to gallbladder disease or dysfunction.

In summary, while there is a long tradition of using these herbal ingredients to support the liver and by extension, the gall bladder, scientific evidence is limited and generally indirect. The use of proprietary blends for gall bladder support relies much more on historical precedent and anecdote than on rigorous, targeted clinical research.