Evidence supporting the use of: Saffron
For the body system: Female Reproductive System
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Saffron (Crocus sativus) has a long history of use in traditional medicine, including Persian, Ayurvedic, and other systems, for supporting female reproductive health—particularly for easing menstrual discomfort and supporting mood. More recently, scientific studies have begun to validate some of these traditional uses. Clinical trials have shown that saffron supplementation (typically 30 mg/day) can improve symptoms of premenstrual syndrome (PMS) and dysmenorrhea (painful periods) compared to placebo. Saffron’s active compounds, such as crocin and safranal, are thought to modulate neurotransmitters like serotonin, which may explain its benefits on mood-related symptoms and its potential to alleviate mood swings and depressive symptoms associated with PMS and perimenopause.
In a 2015 double-blind, randomized controlled trial, saffron was found to be effective in reducing PMS symptoms. Other studies have found saffron may help with mild to moderate depression, which is often co-morbid with reproductive hormonal changes. However, while the evidence for mood and PMS support is promising, there is less robust evidence for saffron affecting other aspects of female reproductive health, such as fertility or hormonal regulation, and more research is needed. Overall, saffron’s use for supporting the female reproductive system is supported by both traditional use and emerging scientific evidence, especially in the context of PMS and mood support.
Other ingredients that support Female Reproductive System
7-hydroxymatairesinol (HMR)amino acids
ashwagandha
basil
black cohosh
borage oil
broccoli
chaste tree
turmeric
d-alpha tocopherol
damiana
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
evening primrose oil
fennel
fenugreek
flaxseed
folate
gamma linolenic acid (GLA)
genistein
ginger
goldenseal
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
inositol
jujube
lactobacillus acidophilus
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus jensenii
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lignans
linoleic acid (LA)
maca
marine lipid
motherwort
nettle
omega-3 fatty acids
raspberry
rose oil
saffron
selenium
soybean
spearmint leaf
tribulus
vitamin B
vitamin B6
vitamin E
wild yam
red clover
squawvine
mugwort
anise
caesalpinia crista
rubia cordifolia
blessed thistle
peony
lingzhi
lingusticum wallichii
yarrow
yarrow
dioscorea
dodder
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
shepherd's purse
wood betony
herbal blend (proprietary)
soy isoflavones
27-deoxyactein
25-d-spirosta-3, 5-diene
8-Prenylnaringenin
Angelica
Anamu
AHCC
Alchemilla
Aletris
Anserina
Anemone
Agnuside
Ashoka
Abuta
Animal protein
Betony
Blue Cohosh
Bugbane
Bethroot
Barbasco
Belamcanda
Bird's nest
Calochortus
Cohosh
Clary sage
Cnidium
Cynomorium
Cramp Bark
Chinese Pond Turtle
Chlorophytum
Casticin
Ceylon Leadwort
Crinum latifolium
DHEA
Daidzein
Dong Quai
Diosgenin
Date
Egg
Erythrina
Evening Primrose Oil
Estrogen
Folic Acid
Fo-Ti
Furostanols
formononetin
Fatty acids
False Unicorn Root
Ginsenosides
Goat's rue
Giant Trillium
Golden Ragwort
Isoflavones
jasmine
Pennyroyal
Rose
Soy Protein
Vervain
Other body systems supported by saffron
BloodBrain
Digestive System
Eyes
Female Reproductive System
Heart
Immune System
Liver
Male Reproductive System
Nerves
Reproductive System
Serotonin
Skin