Evidence supporting the use of: Zeaxanthin
For the health condition: Eyesight (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Zeaxanthin is a dietary carotenoid found in high concentrations in the macula of the human retina, where it plays a crucial role in maintaining eye health and function. Scientific research supports the use of zeaxanthin for supporting and potentially improving poor eyesight, particularly in relation to age-related macular degeneration (AMD), a leading cause of vision loss. Multiple large-scale studies, including the Age-Related Eye Disease Study 2 (AREDS2), have demonstrated that supplementation with zeaxanthin (often in combination with lutein) can slow the progression of intermediate to advanced AMD. Zeaxanthin functions as an antioxidant and filters high-energy blue light, thereby protecting retinal cells from oxidative stress and photodamage. The protective effects are especially notable in populations with low dietary intake of zeaxanthin-rich foods such as leafy greens and brightly colored vegetables. While zeaxanthin supplementation has not been conclusively shown to reverse existing poor eyesight or restore lost vision, there is robust evidence that it can help preserve visual function and reduce the risk of further deterioration in certain eye conditions. The strength of evidence is moderate to high (rated 4/5), based on randomized controlled trials, meta-analyses, and mechanistic studies. However, for general vision improvement in healthy individuals without macular disease, the benefits are less clear, and more research is needed.

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