Evidence supporting the use of: Polyphenols (various)
For the body system: Eyes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols, a diverse group of naturally occurring compounds found in plants, have been studied for their potential role in supporting eye health. Scientific interest primarily focuses on their antioxidant and anti-inflammatory properties, which may help protect ocular tissues from oxidative stress—a key factor in the development of age-related eye diseases such as age-related macular degeneration (AMD) and cataracts. Some epidemiological studies and small clinical trials suggest that diets rich in polyphenols, especially flavonoids and anthocyanins (found in berries, tea, and certain vegetables), are associated with a reduced risk of AMD and improved retinal health. For example, resveratrol (a stilbene polyphenol) and epigallocatechin gallate (EGCG, a catechin polyphenol in green tea) have demonstrated protective effects in animal and in vitro models of retinal degeneration by reducing oxidative damage and modulating inflammation. However, while these findings are promising, the direct evidence from large-scale, long-term human clinical trials is limited, and most current data derive from observational studies or basic research. Thus, while there is a scientific rationale and some supportive evidence for the use of polyphenols in eye health, more robust clinical trials are needed to confirm their efficacy and establish guidelines for supplementation.

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