Mixed carotenoids, including compounds such as beta-carotene, lutein, and zeaxanthin, have scientific evidence supporting their role in eye health. Studies indicate that certain carotenoids are concentrated in the macula of the human retina, where they play a protective role against oxidative damage caused by blue light and free radicals. Lutein and zeaxanthin, in particular, have been shown to filter blue light and act as antioxidants, which may help reduce the risk or progression of age-related macular degeneration (AMD).

The Age-Related Eye Disease Study 2 (AREDS2), a large, multicenter clinical trial sponsored by the National Eye Institute, found that supplementation with lutein and zeaxanthin (in place of beta-carotene) modestly reduced the progression to advanced AMD in individuals at high risk. Epidemiological studies have also associated higher dietary intake of these carotenoids with a lower risk of cataract formation and AMD.

While beta-carotene is a precursor to vitamin A—essential for normal vision—its supplementation is no longer recommended for smokers due to increased lung cancer risk observed in some studies. Instead, lutein and zeaxanthin are considered safer and more directly beneficial for ocular health. Overall, the use of mixed carotenoids, particularly those with lutein and zeaxanthin, is scientifically validated as a supportive measure for maintaining eye health and reducing the risk of degenerative eye conditions.