Evidence supporting the use of: Lutein
For the health condition: Eye Problems

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lutein is a carotenoid found in high concentrations in the macula of the human eye, where it plays a crucial role in filtering harmful blue light and protecting retinal tissues from oxidative stress. There is a substantial body of scientific evidence supporting the use of lutein for eye health, particularly in the context of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. Multiple observational studies have shown that individuals with higher dietary intake or blood levels of lutein have a lower risk of developing AMD and cataracts. Randomized controlled trials, such as the Age-Related Eye Disease Study 2 (AREDS2), demonstrated that supplementation with lutein and zeaxanthin (another carotenoid) can modestly reduce the progression of AMD in individuals at high risk, especially when replacing beta-carotene in the supplement formulation.

Lutein's protective effect is attributed to its antioxidant properties and its ability to absorb blue light, thereby reducing light-induced oxidative damage to retinal cells. Although the evidence is strongest for its role in AMD, there is also some support for lutein's benefit in improving visual performance and contrast sensitivity. Overall, the scientific consensus supports the use of lutein supplements or lutein-rich foods as part of a strategy to maintain eye health, particularly in populations at risk for retinal diseases. However, lutein supplementation is not a cure and works best as a preventive or supportive measure.

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