Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Hypromellose, also known as hydroxypropyl methylcellulose (HPMC), is widely used in ophthalmology as an artificial tear and ocular lubricant. Its use is supported by scientific evidence, primarily for the symptomatic relief of dry eyes (keratoconjunctivitis sicca), as well as for temporary relief of discomfort due to minor irritations of the eye or to exposure to wind or sun.

The mechanism of action of hypromellose is based on its ability to mimic natural tears, forming a lubricating and protective film over the corneal surface. Clinical studies and meta-analyses have demonstrated that hypromellose can significantly reduce symptoms of ocular dryness, burning, and irritation. It is considered safe, with minimal side effects due to its non-irritating and non-sensitizing properties. Hypromellose is also used as a wetting agent during ocular examinations and surgical procedures.

International guidelines and consensus documents, such as those by the Tear Film & Ocular Surface Society (TFOS) and the American Academy of Ophthalmology, recognize hypromellose-based artificial tears as a standard first-line therapy for dry eye disease. While there are other, sometimes more advanced, lubricating agents, the efficacy and safety of hypromellose are well established by decades of clinical use and research.

In summary, hypromellose is scientifically validated as a safe and effective treatment for mild to moderate dry eye and related ocular surface discomfort, and its use is strongly supported by the medical literature and clinical practice guidelines.

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