Evidence supporting the use of: Goldenseal
For the health condition: Eye Problems

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Goldenseal (Hydrastis canadensis) has a long history of traditional use in North American herbal medicine, particularly among Native American tribes and later by European settlers. One of its historical applications included the treatment of eye problems, especially as a topical wash for conjunctivitis (“pink eye”) and general eye irritation. The traditional use was likely driven by goldenseal’s notable yellow color, which comes from the alkaloid berberine—an antimicrobial compound—as well as its astringent properties. Folk medicine texts from the 19th and early 20th centuries describe goldenseal water as an eye wash. However, scientific research on the efficacy and safety of goldenseal for eye conditions is minimal. Modern clinical trials are lacking, and there are concerns about potential irritation or toxicity when used directly in the eye. While in vitro studies show berberine has antimicrobial activity, these results have not been directly translated into validated ophthalmic treatments. Thus, goldenseal’s use for eye problems is justified primarily by tradition, not by strong scientific evidence. Most contemporary herbalists and medical professionals recommend against using goldenseal in or around the eyes due to insufficient evidence and safety data.

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