Evidence supporting the use of: Endopeptidase
For the health condition: Exercise

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endopeptidases are a class of proteolytic enzymes that break down peptide bonds within protein molecules. Their use in relation to exercise is primarily based on their ability to aid in protein digestion and absorption, potentially supporting muscle recovery and reducing exercise-induced muscle soreness. Several studies have investigated proteolytic enzyme supplements (including endopeptidases such as bromelain, papain, and fungal proteases) for their effects on muscle damage, recovery, and inflammation following intensive exercise. Some small-scale clinical trials and pilot studies have reported reductions in muscle soreness and faster recovery when proteolytic enzyme blends are taken post-exercise, possibly due to anti-inflammatory effects and enhanced clearance of muscle breakdown products. However, the evidence is not robust: studies often use mixed enzyme formulations, sample sizes are small, and results are variable. The mechanism of action is hypothesized to involve improved protein turnover and modulation of inflammatory processes, but direct evidence for endopeptidases alone (as opposed to blended protease formulas) is limited. Meta-analyses and systematic reviews generally conclude that while there is some promise, more rigorous and larger-scale trials are needed to confirm the efficacy and safety of endopeptidase supplementation for exercise recovery. Therefore, the use of endopeptidases in exercise contexts is grounded in emerging scientific evidence, but this evidence is currently modest and not definitive.

More about Endopeptidase
More about Exercise

Products containing Endopeptidase

We currently have no products on Caring Sunshine that contain this ingredient.