Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Adenosine 5'-triphosphate disodium (ATP) has been investigated for its potential to improve exercise performance, primarily due to its fundamental role as the body's main energy currency. Scientific interest is based on the hypothesis that supplemental ATP may enhance muscular energy availability, delay fatigue, or aid recovery. Several small clinical studies and pilot trials have examined oral ATP supplementation and its effects on strength, power, and fatigue resistance. Some of these studies have shown modest improvements in muscle strength, power output, or recovery in resistance-trained athletes, particularly when moderate to high doses are used. However, the effects are inconsistent, and many studies have failed to show significant benefits compared to placebo.

One of the main challenges is that orally ingested ATP is rapidly broken down in the gastrointestinal tract, leading to questions about its bioavailability and direct efficacy. Some researchers speculate that ATP or its metabolites could exert signaling effects, promoting vasodilation or improved blood flow to muscles, indirectly supporting exercise performance. The current scientific consensus, however, is that there is limited and inconsistent evidence supporting ATP supplementation for exercise performance or recovery. Large, well-controlled trials are lacking, and the overall quality and quantity of evidence is low. As such, while the rationale for ATP use in exercise settings is rooted in basic physiology, robust scientific validation is currently insufficient.

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