Evidence supporting the use of: Glycyrrhiza (unspecified)
For the body system: Estrogen

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhiza, commonly known as licorice root, has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and Ayurveda. In these traditions, it is often employed as a harmonizing herb and for female health concerns, which may include menstrual irregularities or menopausal symptoms. The basis for its use in supporting the estrogen (female hormone) body system is largely due to its phytoestrogen content—specifically, compounds like glabridin and liquiritigenin, which can exhibit weak estrogenic activity in vitro. However, most clinical data are lacking, and the majority of evidence is derived from in vitro studies or animal models rather than robust human trials.

While some laboratory studies suggest that Glycyrrhiza extracts may bind to estrogen receptors or modulate estrogen metabolism, these findings have not translated into consistent, high-quality clinical outcomes. The traditional use persists, especially for symptoms such as hot flashes or premenstrual discomfort, but scientific validation for specific estrogen-related benefits in humans remains limited. Therefore, the evidence supporting its use for the estrogen body system is primarily traditional, with only modest support from preliminary mechanistic studies.

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