Glycetein is an isoflavone compound found primarily in soybeans and other legumes. Isoflavones, such as glycetein, genistein, and daidzein, are classified as phytoestrogens—plant-derived compounds with a chemical structure similar to that of human estrogen. As a result, they can weakly bind to estrogen receptors and exert estrogen-like effects in the body. Several scientific studies have investigated the impact of soy isoflavones, including glycetein, on estrogen-related body systems, particularly in relation to menopausal symptoms, bone health, and cardiovascular function in women.

The evidence supporting the use of glycetein to support the estrogen body system is moderate. Clinical trials and meta-analyses suggest that soy isoflavone supplementation can modestly alleviate certain menopausal symptoms, such as hot flashes, and may contribute to bone density maintenance. However, most research evaluates the effects of total isoflavones or soy protein rather than isolated glycetein. While the estrogenic activity of glycetein is weaker than that of genistein or daidzein, it is still considered to play a role in the overall phytoestrogenic effect of soy-based interventions.

In summary, there is scientific evidence—though not overwhelmingly strong—supporting the use of glycetein as part of a group of soy isoflavones to support the estrogen body system, particularly for menopausal health. The rating reflects the fact that most evidence is indirect or as part of a mixture, rather than specifically focused on glycetein alone.