Evidence supporting the use of: Flax lignans
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flax lignans, particularly secoisolariciresinol diglucoside (SDG), are phytoestrogens—plant-derived compounds structurally similar to estrogen. These compounds can exert weak estrogenic or anti-estrogenic effects by binding to estrogen receptors in the body. Several clinical and preclinical studies suggest that flax lignans may help modulate estrogen metabolism and support hormonal balance, especially in women. For example, research has shown that regular flaxseed consumption can mildly increase levels of 2-hydroxyestrone, a metabolite associated with a lower risk of estrogen-related cancers, and reduce levels of more potent estrogen metabolites. Randomized controlled trials and observational studies have explored the effects of flaxseed supplementation in peri- and postmenopausal women, with some reporting reductions in menopausal symptoms such as hot flashes. However, results are mixed, and effect sizes tend to be modest. Flax lignans have also been investigated for their potential roles in breast health and menstrual cycle regulation, but definitive conclusions are limited by study size and design variability. Overall, while flax lignans are traditionally consumed in several cultures, their use to support the estrogen system is primarily supported by emerging scientific evidence, though more robust and long-term studies are needed to confirm their effectiveness and clarify mechanisms.

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