Evidence supporting the use of: Five-leaf Chastetree
For the body system: Estrogen

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Five-leaf Chastetree (Vitex negundo), sometimes confused with the more widely used Chaste Tree (Vitex agnus-castus), has a long history in traditional medicine, especially in South and Southeast Asia. In traditional systems such as Ayurveda and Unani, Five-leaf Chastetree has been used for a variety of purposes, including supporting women’s reproductive health. However, most of the traditional use focuses on its anti-inflammatory, analgesic, and antimicrobial properties, with less direct reference to estrogenic or hormonal modulation. Some ethnobotanical sources suggest its use for menstrual disorders, but documentation is not as established as with Vitex agnus-castus. Scientific research on Five-leaf Chastetree specifically for supporting the estrogen body system is limited. Most clinical and preclinical studies that suggest hormonal or estrogen-modulating effects actually pertain to Vitex agnus-castus, not Vitex negundo. For Vitex negundo, there are a few animal studies indicating potential effects on reproductive hormones, but these are preliminary and not robust enough to establish efficacy or mechanism in humans. In summary, the use of Five-leaf Chastetree for supporting the estrogen body system is primarily based on traditional usage, with limited and low-quality scientific evidence. Most data supporting hormonal effects pertain to a related but different species.

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Products containing Five-leaf Chastetree

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