Evidence supporting the use of: 4-Hydroxyandrostenedione
For the body system: Estrogen

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 5

4-Hydroxyandrostenedione (also known as formestane) is a steroidal aromatase inhibitor that has been used clinically to support the estrogen body system, primarily in the context of hormone-dependent breast cancer. Aromatase is the enzyme responsible for the conversion of androgens to estrogens. By inhibiting aromatase, 4-hydroxyandrostenedione significantly reduces estrogen production in the body. This property led to its approval and use as a treatment for postmenopausal women with estrogen receptor-positive breast cancer. Numerous randomized clinical trials and meta-analyses have demonstrated its efficacy in lowering systemic estrogen levels and reducing tumor progression in this context. While newer, non-steroidal aromatase inhibitors (like anastrozole and letrozole) have largely replaced formestane due to improved oral bioavailability, the mechanism and clinical effects of 4-hydroxyandrostenedione are well documented in the scientific literature. Thus, its use to modulate and support the estrogen body system, specifically by reducing excessive estrogen in hormone-dependent cancers, is strongly supported by scientific evidence. However, it is not used to support estrogen production but rather to suppress it when clinically indicated.

More about 4-Hydroxyandrostenedione
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Other body systems supported by 4-Hydroxyandrostenedione

Estrogen

Products containing 4-Hydroxyandrostenedione

We currently have no products on Caring Sunshine that contain this ingredient.