Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutamine is an amino acid involved in several metabolic processes, including serving as a fuel source for rapidly dividing cells such as those in the immune and gastrointestinal systems. Its role in supporting energy, particularly in the context of "lack of energy" or fatigue, is an area of ongoing study. Scientific evidence primarily supports its use in specific clinical circumstances rather than general fatigue or low energy in healthy individuals. For example, glutamine supplementation has been shown to benefit individuals under extreme physical stress, such as athletes during intense training, by supporting muscle recovery and reducing markers of muscle damage. Glutamine is also conditionally essential during periods of illness, injury, or metabolic stress, when endogenous production may not meet the body's increased needs. There is limited direct evidence supporting its efficacy as a general energy booster for otherwise healthy people experiencing fatigue. Some small studies suggest that glutamine may help reduce fatigue in cancer patients undergoing chemotherapy or after major surgery, but these findings are not robust or widely replicated. Overall, while there is a biochemical rationale for glutamine’s involvement in energy metabolism—particularly in the context of stress or illness—current scientific validation for its use to treat general "lack of energy" is weak. Thus, glutamine should not be regarded as a primary intervention for boosting energy in the general population.

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Other ingredients used for Energy (lack of)

Other health conditions supported by l-glutamine

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