Calotropis gigantea, commonly known as crown flower or giant milkweed, has been traditionally used in various systems of medicine, including Ayurveda and folk medicine, to treat a range of ailments, including edema (swelling due to fluid retention). The traditional use of Calotropis gigantea for edema is based largely on its reputed diuretic and anti-inflammatory properties. In Ayurveda, parts of the plant—especially the root and leaves—are used in the management of swelling and fluid accumulation.

Some preliminary pharmacological studies have suggested that extracts from C. gigantea may possess anti-inflammatory and diuretic effects in animal models, which could justify its use for edema. However, these studies are limited in number, typically preclinical, and often do not directly focus on edema as a primary endpoint. There is a lack of robust, high-quality clinical trials in humans specifically investigating its efficacy and safety for this condition. Therefore, the evidence for its use remains largely traditional, with a small amount of low-level scientific support. Caution is advised because the plant is known to contain toxic compounds, such as cardiac glycosides, which can be harmful if not used appropriately.

In summary, Calotropis gigantea has a history of traditional use for edema, but scientific validation is limited and not yet sufficient to fully endorse its use for this indication.