Evidence supporting the use of: Alpha-linolenic acid (ALA)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-linolenic acid (ALA) has some scientific support for its use in the management of dysmenorrhea (painful menstruation), though the evidence is not robust. ALA is an omega-3 fatty acid found in plant sources such as flaxseed, chia seeds, and walnuts. Omega-3 fatty acids are thought to have anti-inflammatory properties that may help reduce menstrual pain, which is believed to be partly due to the production of pro-inflammatory prostaglandins in the uterus. A limited number of clinical studies have investigated the effects of omega-3 fatty acids, including ALA, on dysmenorrhea. Most research has focused on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are longer-chain omega-3s derived from ALA. However, a few studies suggest that increased intake of ALA-rich foods or supplements may help decrease the severity of menstrual pain. For example, a randomized controlled trial published in Obstetrics & Gynecology Science (2018) found that flaxseed supplementation (a rich source of ALA) led to a significant reduction in menstrual pain intensity compared to placebo. The mechanism is thought to involve the modulation of prostaglandin synthesis, reducing uterine contractions and inflammation. Overall, while there is some preliminary scientific evidence suggesting a benefit of ALA in dysmenorrhea, more high-quality, large-scale studies are needed. The evidence is currently rated as weak to moderate (2/5), and ALA should not be considered a primary or sole treatment for dysmenorrhea but may be considered as a complementary approach.

More about alpha-linolenic acid (ALA)
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