Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allantoin is a compound commonly included in topical formulations for its skin-soothing and healing properties. Its use in diaper rash treatments is supported to some extent by scientific evidence, though the strength of that evidence is moderate. Allantoin has been shown in laboratory and some clinical studies to promote skin cell proliferation and aid in wound healing, which can be beneficial in managing minor skin irritations such as those caused by diaper rash. It also acts as a skin protectant by forming a barrier that helps retain moisture and shields the skin from further irritation.

The U.S. Food and Drug Administration (FDA) recognizes allantoin as a safe and effective over-the-counter skin protectant for minor skin irritations, including diaper rash, under specific concentrations (generally 0.5% to 2%). While allantoin is regularly included in many commercial diaper rash creams, there is a lack of large-scale, high-quality clinical trials specifically evaluating its efficacy for diaper rash compared to other agents like zinc oxide or petrolatum. Most supporting evidence comes from its general skin protectant and healing properties rather than targeted studies on diaper dermatitis. Therefore, while allantoin is scientifically justified for use in diaper rash products, the direct evidence for its effectiveness in this specific condition is limited, leading to a moderate (2/5) evidence rating.

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