Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B5, also known as pantothenic acid, has some scientific evidence supporting its use in the management of dermatitis, particularly in the context of deficiency states. Pantothenic acid is essential for the synthesis and maintenance of coenzyme A, which is important in fatty acid metabolism and skin barrier function. Historically, severe B5 deficiency (rare in developed countries) can result in symptoms including dermatitis, but such cases are uncommon.

Some animal studies have suggested that B5 supplementation may improve skin barrier function and reduce inflammation. Limited clinical data in humans suggest possible benefits for wound healing and skin hydration, but well-controlled trials specifically evaluating B5 supplementation for the treatment of dermatitis (such as atopic dermatitis or contact dermatitis) are lacking. The European Food Safety Authority acknowledges B5’s role in normal skin function, but it does not specifically endorse its use for dermatitis treatment.

Overall, while there is some biological plausibility and weak clinical evidence for a role in skin health, there is insufficient high-quality clinical evidence to support routine use of vitamin B5 supplements as a treatment for dermatitis in the absence of deficiency. The current evidence base is best characterized as weak (rated 2/5).

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