Evidence supporting the use of: Salidroside
For the health condition: Depression

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salidroside is a bioactive compound found in Rhodiola rosea, a traditional adaptogenic herb used in various cultures, especially in Russia and Scandinavia, to combat fatigue and enhance mental performance. There is emerging scientific interest in salidroside’s potential antidepressant effects. Preclinical studies in animal models have demonstrated that salidroside can reduce depressive-like behaviors, possibly through modulation of neurotransmitters such as serotonin, dopamine, and norepinephrine, as well as by reducing neuroinflammation and oxidative stress. Some small-scale human studies and clinical trials using Rhodiola rosea extracts (which contain salidroside among other compounds) suggest mild to moderate efficacy in alleviating symptoms of depression, particularly in cases of mild to moderate major depressive disorder.

However, high-quality, large-scale randomized controlled trials specifically investigating isolated salidroside in human depression are lacking. Most clinical studies have focused on the whole plant extract rather than the isolated compound. Therefore, while there is a scientific rationale and some preliminary evidence for the use of salidroside in supporting depression, the overall quality and quantity of clinical data is limited, justifying a moderate evidence rating. Further research is necessary to firmly establish its efficacy and safety for this indication.

More about Salidroside
More about Depression

Other ingredients used for Depression

5-Hydroxytryptophan (5-HTP)
Acetyl L-carnitine
algal oil
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
ashwagandha
Waterhyssop
basil
bergamot
beta caryophyllene
Bifidobacterium longum
black tea
Indian frankincense
bасора
caffeine
Cannabis sativa oil
chamomile
Chinese salvia root
choline
citicoline
clove
coenzyme Q10 (CoQ10)
cordyceps
creatine monohydrate
turmeric
curcumin
damiana
DHA (docosahexaenoic acid)
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish oil
fish protein
flavonols
folate
gardenia
ginger
ginkgo biloba
ginseng
gotu kola
Greek mountain tea
green tea
hemp oil
Indian tinospora
inositol
jujube
krill oil
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-carnosine
L-glycine
L-methionine
L-phenylalanine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lavender
lion's mane
lithium orotate
liquid liver fractions
luteolin
maca
magnesium
magnolia
Marine lipid
Matcha
Melatonin
Moringa
Muira puama
N-acetyl-cysteine (NAC)
Acetyl-L-Tyrosine
omega-3 fatty acids
phenolic compounds
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
prebiotic blend (proprietary)
pregnenolone
protein
butyric acid
quercetin
reishi mushroom
resveratrol
Rhodiola
rose oil
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
sceletium
selenium
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
spirulina
Tongkat ali
Almond fruit
Valerian root
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
Whey protein
Zinc
suma
gastrodia
Mugwort
alpinia galangal
commiphora
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lingzhi
lemongrass
kanna
cistanche
dodder
Morinda
royal jelly
polyphenols
trace minerals
St. John's Wort
Yerba mate
cocoa
thyroid substance
star of Bethlehem
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
arginine creatine
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Angelica
apigenin
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Alpha lactalbumin
Asteraceae
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aniracetam
Amor seco
betony
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Beef liver
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bee products
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biogenic amine
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coconut
caryophyllene
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crocin
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catalpol
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chocolate
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docosahexaenoic Acid
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devil\'s club
dopamine
egg
Eicosatetraenoic acid
eicosapentaenoic acid
estrogen
folinic acid
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flavonoids
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fish
fatty acids
fungus
frankincense
guanidinoacetic acid
Ginsenosides
Griffonia simplicifolia
Gypenoside
Glutamate
Glycine
gastrodin
Honokiol
Hypericin
Hellebore
Hypericum
hyperforin
Helicteres isora
hericium mushroom
hemp
isoliquiritigenin
long pepper
icariin
Indian fagonia
inositol phosphate
jasmine
Jatamansi
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lemon balm
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ligustilides
limonene
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little ironweed
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magnolol
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Oroxylum indicum
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Osthole
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rue
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Rubiaceae
rose
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Sete sangrias
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Salvia
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Salidroside
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Wulinshen
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Xanthophyll
Xylaria nigripes
Yuzu
Yerba buena
Yohimbine
Ylang ylang
Zucchini
Zingiberene

Products containing Salidroside

We currently have no products on Caring Sunshine that contain this ingredient.