Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rhodiola rosea, also known as "golden root," has a long history of use in traditional medicine systems in Russia, Scandinavia, and other parts of Europe and Asia for improving endurance, reducing fatigue, and enhancing resilience to stress. In recent years, it has also been studied for its potential antidepressant effects. Several clinical trials and review articles have examined Rhodiola’s efficacy in managing depressive symptoms, with mixed but promising results.

Some randomized controlled trials (RCTs) have found that Rhodiola extract, particularly SHR-5, can significantly reduce depressive symptoms compared to placebo, especially in individuals with mild to moderate depression. For example, a 2007 double-blind RCT by Darbinyan et al. showed improvements in depression, insomnia, and emotional instability with Rhodiola supplementation. The proposed mechanisms include modulation of neurotransmitters such as serotonin, dopamine, and norepinephrine, as well as effects on the hypothalamic-pituitary-adrenal (HPA) axis.

However, the overall quality of evidence remains moderate due to small sample sizes, short study durations, and occasional lack of replication. Meta-analyses and systematic reviews tend to agree that while there is some scientific support for Rhodiola’s role in reducing depressive symptoms, more rigorous, large-scale studies are needed to confirm its effectiveness and safety. Thus, while Rhodiola’s use for depression is justified with some scientific support, it should not replace conventional antidepressant treatments for moderate to severe cases.

More about rhodiola
More about Depression

Other ingredients used for Depression

Other health conditions supported by rhodiola

Products containing rhodiola

Nature's Sunshine AdaptaMax
Nature's Sunshine Glandular System
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Power Greens
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Ultra Therm CF