Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Clary sage (Salvia sclarea) essential oil is sometimes used as a complementary approach to support mood and alleviate symptoms of depression. The justification for its use is primarily based on a combination of limited scientific research and its traditional application in aromatherapy. Some small-scale human studies and animal models suggest that inhalation or topical application of clary sage oil may have an antidepressant-like effect. For example, a 2014 study published in the Journal of Ethnopharmacology reported that inhalation of clary sage oil by menopausal women led to a significant reduction in cortisol levels and an increase in 5-HT (serotonin) levels, both of which are implicated in mood regulation. Another animal study found clary sage oil exhibited anti-stress and antidepressant-like effects in rats. These findings are thought to be related to certain constituents in the oil, such as linalyl acetate and linalool, which may interact with neurotransmitter systems.

However, the overall quality and quantity of evidence are limited. Most studies have small sample sizes, lack rigorous controls, or have not been replicated in larger, diverse populations. While traditional aromatherapy often includes clary sage for mood support, there is not enough robust scientific data to recommend it as a primary treatment for depression. It should be considered as a complementary approach, not a substitute for evidence-based medical therapies.

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