Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Chloride is scientifically validated as a critical component in the treatment and prevention of dehydration. Dehydration frequently results in the loss of both water and electrolytes, particularly sodium and chloride, which are the main ions found in extracellular fluid. Chloride, typically administered as part of sodium chloride (NaCl, or common table salt), plays a vital role in maintaining osmotic balance, acid-base equilibrium, and proper cellular function. Clinical guidelines from organizations such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) recommend the use of oral rehydration solutions (ORS) that contain sodium chloride, potassium chloride, and glucose to effectively treat dehydration, especially that caused by diarrhea or vomiting. These solutions are formulated to replace both fluid and essential electrolytes, including chloride, lost during dehydration.

Numerous clinical trials and decades of practical use have demonstrated that rehydration therapies containing chloride significantly reduce mortality and morbidity associated with dehydration, particularly in children with diarrheal diseases. The inclusion of chloride is essential not only to restore electrolyte balance but also to aid sodium absorption in the intestines, as sodium and chloride co-transport is a key mechanism in water absorption. Therefore, the use of chloride in dehydration treatments is strongly supported by scientific evidence and is an integral part of standard medical practice worldwide.

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