Glandular tissues, such as extracts from animal glands (e.g., adrenal, thyroid, thymus), have a long history of use in traditional and alternative medicine systems for the management of "debility"—a general state of physical weakness or lack of energy. The rationale behind their use stems from the principle of "like supports like" or organotherapy, where it is believed that consuming animal glands can support or revitalize the corresponding human organs, thereby improving overall vigor and addressing states of debility. This practice was especially popular in the late 19th and early 20th centuries before the advent of modern endocrinology. However, scientific evaluation of glandular supplements for debility is limited and inconsistent. Most claims are not supported by controlled clinical trials, and the efficacy remains largely anecdotal or based on traditional beliefs rather than robust scientific evidence. The regulatory status of glandular extracts varies, and concerns about safety, consistency, and the potential for pathogen transmission have further limited their mainstream acceptance. While some early medical literature and case reports suggested benefits, these are not considered high-quality evidence by current standards. In summary, the use of glandular tissues to treat debility is primarily justified by tradition, with minimal scientific validation available.