Prickly ash, referring to species such as Zanthoxylum americanum or Zanthoxylum bungeanum, has a history of use in traditional medicine systems, particularly in North America and parts of Asia. Its primary traditional uses include treatments for digestive complaints, pain, circulatory issues, and as a general stimulant. There is some anecdotal and ethnobotanical evidence that prickly ash was used in traditional formulations as a remedy for various skin conditions, but direct references to its use specifically for dandruff are limited and not well documented in primary historical sources. In some traditional herbal practices, prickly ash has been included in topical preparations aimed at promoting scalp health, likely due to its purported antimicrobial and circulatory-stimulating properties. However, there is no robust scientific evidence or clinical trials evaluating its efficacy for treating dandruff (seborrheic dermatitis). The evidence for its use in this context is therefore rated as very weak, relying primarily on extrapolation from its broader use in traditional medicine for skin and scalp issues, rather than direct evidence or scientific validation. In summary, prickly ash’s use for dandruff is primarily tradition-based with minimal supporting evidence, and it should not be considered a scientifically validated remedy for this condition.