Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactococcus lactis is a probiotic bacterium widely used in the dairy industry for fermentation, but its role in the support or treatment of Crohn's Disease (CD) is based on emerging scientific interest rather than long-standing tradition. Experimental evidence, primarily from animal models and a limited number of early-phase human studies, suggests that L. lactis may have potential in modulating intestinal inflammation associated with CD. One of the main mechanisms proposed is its ability to deliver therapeutic molecules directly to the gut mucosa. For example, genetically engineered strains of L. lactis have been used to secrete anti-inflammatory cytokines such as interleukin-10 (IL-10), which have shown promise in reducing inflammation in mouse models of colitis, a condition closely related to CD (Steidler et al., Science, 2000). However, robust human clinical trial data are still lacking. While some early-phase studies indicate that L. lactis may be safe and potentially beneficial as an adjunct therapy, there is not yet sufficient evidence to support its routine use in clinical practice for Crohn's Disease. Its use is not rooted in traditional medicine but is a product of modern biotechnological approaches. Thus, while the use of L. lactis for Crohn's Disease is scientifically motivated and shows potential, the current level of evidence is modest and further research is needed to establish efficacy and safety in humans.

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